Spike Timing-dependent Plasticity Figure (IMAGE)

Osaka University

Spike Timing-dependent Plasticity Figure

Caption

Two opposite forms of spike timing-dependent plasticity (STDP) converge onto L2/3, spike timing-dependent long-term potentiation (t-LTP) from L4 and spike timing-dependent long-term depression (t-LTD) from the thalamus during the second postnatal week. Thalamic projection to L4 lost STDP at this age. Thalamic activity may facilitate L4-L2/3 synapse formation by t-LTP, while simultaneously weakening and retracting from direct innervation of L2/3 by t-LTD through CB1R, thus, reorganization of neural circuits may proceed in a self-organizing manner. Illustration adapted from Itami et al (2016) with modifications.

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Osaka University

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