HTLV-1 Infection (IMAGE)

Kyoto University

HTLV-1 Infection

Caption

HTLV-1 establishes infection mainly in CD4+ T cells and induces leukemia. HTLV-1-encoded Tax is a critical transactivator of viral replication, but its significance in pathogenesis remained unclear. The research team showed that Tax is expressed in a fraction of leukemic cells and its expression spontaneously switches between on and off states.

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Kyoto University / Jun-ichirou Yasunaga

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