Schematic drawing of EGFR-mediated keratinocyte stem cell motility regulated by COL17A1 proteolysis. (IMAGE)

Tokyo Medical and Dental University

Schematic drawing of EGFR-mediated keratinocyte stem cell motility regulated by COL17A1 proteolysis.

Caption

EGFR signaling stabilizes COL17A1 through TIMP1 induction, which is required for cell motility coordinated by actin and keratin filament networks. The age-associated decline of EGFR signaling results in impaired reepithelialization and skin regeneration. MPs, metalloproteinases.

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Department of Stem Cell Biology, TMDU

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