The Difference of Signaling Pathways Between Previously Known Cell Death Prototypes and TRIAD (IMAGE)

Tokyo Medical and Dental University

The Difference of Signaling Pathways Between Previously Known Cell Death Prototypes and TRIAD

Caption

Apoptosis or necroptosis is induced by cell death signaling. Contrarily, transcriptional repression-induced cell death (TRIAD) is induced by the loss of survival signal mediated by Hippo pathway. Phosphorylation of YAP by LATS1/2 or sequestration of YAP by mutant Htt prevents nuclear translocation of YAP and TEAD-YAP transcription that is essential for cell survival of neurons.

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Department of Neuropathology,Medical Research Institute

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