Disease Tolerance in Tuberculosis (IMAGE)

McGill University Health Centre

Disease Tolerance in Tuberculosis

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This is a colored X-ray of a patient's chest showing disseminated, or miliary, tuberculosis (TB) in the lungs and if left untreated, it has almost 100 percent mortality rate. The lungs contain lesions (tubercles, pink) consisting of infected dead tissue. Using mouse models of TB, Tzelepis et al, have identified the critical role of mitochondrial Cyclophilin D for regulating T cell mediated immunity in disease tolerance independent of host resistance to Mycobacterium tuberculosis.

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DU CANE MEDICAL IMAGING LTD/SCIENCE PHOTO LIBRARY

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