Semisynthesis of Homogeneous Glycoproteins (IMAGE)

Wiley

Semisynthesis of Homogeneous Glycoproteins

Caption

The efficient formation of mixed disulfides on the thiol-rich fusion protein A followed by subsequent intein cleavage gave the fragment B with all seven cysteines protected against oxidation. The native chemical ligation of B with synthetic glycopeptide thioesters provides glycoproteins.

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(C) Wiley-VCH

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Permission to use with appropriate credit and link to http://dx.doi.org/10.1002/anie.200804734

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