Normal, Diseased and Rescued Voltage Sensor (IMAGE)

University of Washington School of Medicine/UW Medicine

Normal, Diseased and Rescued Voltage Sensor

Caption

The voltage sensor has two cavities (purple) that do not connect. Mutations (red) linked to periodic paralysis allow them to join, thereby creating a pore through which ions can leak. Compounds (blue and yellow) that block the pore could treat the condition.

Credit

Ning Zheng & Catterall labs/UWMedicine

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