α-synuclein Strains (IMAGE)
Caption
α-synuclein strain formation, strain dependent interaction with 26S proteasome and pathologies induced by each strain. In the absence of salt (upper), α-synuclein monomers have exposed C-terminal region with high electric repulsion. These form the α-synuclein strain with exposed C-terminal region and this type of the α-synuclein strain can interact with 26S proteasomes and inhibit their activities resulting the accumulation of phosphorylated α-synuclein aggregates (arrowheads) when inoculated into mouse brain. In the presence of salt (lower), α-synuclein monomers have packed C-terminal region with low electric repulsion. These form the α-synuclein strain with masked C-terminal region and this type of the α-synuclein strain can not interact with 26S proteasomes resulting only few pathologies induced. (Suzuki et al., eLife 2020).
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