Fluorescent Radiography Images (IMAGE)
Caption
Fluorescent radiography images of two wild type (WT, or normal) mice on top and two knockout (KO) mice on bottom. The KO mice are bred without a gene that produces a chaperone protein for protecting against immune activity on healthy cells. The presence of helper T cells and collagen is indicated by the green and orange signals, respectively. KO mice (bottom two images) show higher levels of collagen reactive helper T cells in the joints of the legs, indicating immune activity against collagen, a fibrous protein, and showing that collagen-induced arthritis, a mouse autoimmune disorder, has occurred.
Credit
Johns Hopkins Medicine
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