Endosomal Na/H Exchangers (eNHE) (IMAGE)

Nagoya University

Endosomal Na/H Exchangers (eNHE)

Caption

We suggest endosomal Na/H exchangers (eNHE) as a potential target of metformin action. The eNHEs mostly exist in recycling endosomes and late endosomes to control the pH of these organelles. Metformin might affect the endosomal pathway by affecting eNHEs function and thus by changing the inside pH. This change could affect the speed and process of the trafficking, which somehow could help to alleviate diabetic conditions.

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Young-Jai You

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