IL-17 Autocrine Loop (IMAGE)

NIH/National Eye Institute

IL-17 Autocrine Loop

Caption

After activation through its T-cell receptor, Th17 cells produce IL-17A, which binds to its own receptor on the Th17 cell. This activates the NFκB pathway. NFκB drives production of IL-24, which in turn suppresses the Th17 cytokine program via SOCS1 and 3.

Credit

Rachel Caspi, Ph.D. (NEI)

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