Epigenetics and Gain-of-Function p53 Mutations (IMAGE)

University of Pennsylvania School of Medicine

Epigenetics and Gain-of-Function p53 Mutations

Caption

Gain-of-function p53 mutants are recruited by ETS family proteins to activate genes, including key epigenetic enzymes MLL1, MLL2 and MOZ. This, in turn, results in altered histone modifications genome-wide and may contribute to aggressive cancers associated with p53 mutations.

Credit

Jiajun Zhu, Perelman School of Medicine, University of Pennsylvania

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