E-NTPD8 prevents neutrophil-mediated colitis by hydrolyzing luminal ATP (IMAGE)

Osaka University

E-NTPD8 prevents neutrophil-mediated colitis by hydrolyzing luminal ATP

Caption

E-NTPD8 in colonic epithelial cells maintains gut homeostasis through the hydrolysis of luminal ATP produced by commensal bacteria (left). An increased level of luminal ATP caused by a lack of E-NTPD8 modulates neutrophil physiology, such as prolonged survival through P2X4-mediated promotion of glycolysis. This can then aggravate colitis symptoms (right).

Credit

Haruka Tani et al.

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