Age and Infection (IMAGE)
Caption
A summary of the effects of age and infection at multiple time points after injection of E. coli or saline. Memory = hippocampus-dependent long-term memory; IL-1β = levels of pro-inflammatory cytokine interleukin-1 beta in hippocampal synaptoneurosomes; and L-LTP = theta burst-evoked L-LTP in the hippocampal CA1 area; and BDNF = levels of mature BDNF and activity of related proteins in hippocampal synaptoneurosomes. Upward arrows indicate an increase, and downward arrows show a reduction. Three arrows represent severe deficits, and one arrow means impairments to a lesser degree. Horizontal lines indicate baseline values. Data summarized for Day 4 are drawn from earlier publications: Memory & IL-1β (Barrientos et al., 2006; Barrientos et al., 2009), L-LTP (Chapman et al., 2010), and BDNF (Cortese et al., 2011).
Credit
Tanaka et al., <i>eNeuro</i> (2018)
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