Fig.1 (IMAGE)

Osaka University

Fig.1

Caption

1) Fasting or obesity induces SDF-1 expression in adipocytes. 2) Its autocrine action activates ERK signaling. 3) SDF-1-induced ERK signal concomitantly induces serine phosphorylation of IRS-1 protein, and degrades IRS-1 protein. This attenuates 4) insulin-mediated Akt phosphorylation and 5) glucose uptake.

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Osaka University

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