The Many Faces of Calcium and Cancer (IMAGE)

University of Pennsylvania School of Medicine

The Many Faces of Calcium and Cancer

Caption

Inhibition of low-level endoplasmic reticulum-to-mitochondria calcium ion transfer is toxic, specifically to cancer cells. An unexpected dependency on this transfer to mitochondria exists for a viability of tumorigenic cells, suggesting that mitochondrial calcium ion addiction is a novel feature of cancer cells.

Credit

The lab of Kevin Foskett, Ph.D., Perelman School of Medicine, University of Pennsylvania

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