Graphical Abstract of This Study (IMAGE) Nagoya City University Caption The current study consists of two RNA-sequences analyses from different patients cohorts. Then, the data were computedly analyzed for detecting a responsible gene. The gene expression was validated with human samples and a mouse model; besides, functional analysis was performed with a knockout mouse. Credit © Kazumi Taguchi Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.