Building better antivirals: understanding interactions between drugs and viruses key to being ready for variants and the next pandemic (IMAGE)

University of Alberta Faculty of Medicine & Dentistry

Building better antivirals: understanding interactions between drugs and viruses key to being ready for variants and the next pandemic

Caption

A uniform model of the mechanism of action (MOA) of remdesivir. The light blue oval represents a viral RNA polymerase. The priming strand and template are shown in white and green circles, respectively. 1. Residues of Motif F (dark blue) position the template for nucleotide incorporation. As an example, the incoming uridine triphosphate (UTP) binds the complementary adenosine (A) in the template. 2. The adenosine analog remdesivir (R) contains a bulky modification that clashes with motif F. As a consequence, UTP incorporation is inhibited.

Credit

Matthias Gotte

Usage Restrictions

None

License

Original content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.