Lifespan Methylation Trajectories (IMAGE) NIH/National Institute of Mental Health Caption Two representative genes show strikingly opposite trajectories of PFC methylation across the lifespan. Each dot represents a different brain. Usually, the more methylation, the less gene expression. Credit Barbara Lipska, Ph.D., NIMH Clinical Brain Disorders Branch Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.