Muscle Regeneration in Duchenne Muscular Dystrophy (IMAGE)

Sanford Burnham Prebys

Muscle Regeneration in Duchenne Muscular Dystrophy

Caption

HDAC inhibitors (HDACi) promote muscle regeneration in a mouse model of Duchenne Muscular Dystrophy at early stages of disease by targeting fibro-adipogenic progenitors (FAPs). Staining of FAPs from muscles of HDACi-treated young mdx mice reveals presence of differentiated muscle cells (green) at the expense of fat cells (red). Nuclei are stained in blue.

Credit

Lorenzo Puri, M.D.

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