Amitriptyline Improves Drug Delivery across the Blood-Brain Barrier (IMAGE)

NIH/National Institute of Environmental Health Sciences

Amitriptyline Improves Drug Delivery across the Blood-Brain Barrier

Caption

Normally, P-glycoprotein prevents most medicines from entering the brain by pumping them back into the blood stream (left). The addition of amitriptyline temporarily turns off P-glycoprotein pumps, allowing drug molecules to cross the blood-brain barrier (right).

Credit

NIEHS

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