Toxic Protein Interactions (IMAGE)

St. Jude Children's Research Hospital

Toxic Protein Interactions

Caption

The nucleolar protein NPM1 (green) undergoes phase separation to form liquid droplets when combined with its normal binding partners, and this contributes to the assembly and function of the nucleolus. The ALS-related toxic protein polyGR (red) insinuates itself into these liquid structures and impairs normal function.

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St. Jude Children's Research Hospital / Peipei Zhang

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