Fluorescent microscopy of T and B cells showing germinal center forming in spleen after malaria infection only in a TBK1 positive mouse (IMAGE)

University of Tokyo

Fluorescent microscopy of T and B cells showing germinal center forming in spleen after malaria infection only in a TBK1 positive mouse

Caption

With a healthy immune system, infection causes CD4+ follicular T cells (blue) and immature B cells (red), two types of white blood cell, to form a temporary structure called the germinal center (green) in organs of the immune system. Spleen cells taken from a healthy mouse (left) and a mouse genetically modified to lack the enzyme TBK1 only in B cells (right) show that TBK1 is essential for normal germinal center formation during a malaria infection.

Credit

Image by Michelle S.J. Lee, Creative Commons By Attribution No Derivatives https://creativecommons.org/licenses/by-nd/4.0/

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