KBTBD2 (IMAGE)

UT Southwestern Medical Center

KBTBD2

Caption

The illustration shows the identification of KBTBD2 as a key gene in the maintenance of whole-body insulin sensitivity through its role in fat. Loss of KBTBD2 leads to the accumulation of the protein p85? that blocks insulin signaling in fat and secondary insulin resistance in other tissues such as liver and muscle.

Credit

UT Southwestern Medical Center

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