Neutrophils contribute to thrombosis in patients (IMAGE)

Elsevier

Neutrophils contribute to thrombosis in patients

Caption

A: The number of neutrophil-platelet aggregates per 20x field was quantified in patients and controls. B and C: Patient tissue images of neutrophil-platelet aggregates and a neutrophil during NETosis, capturing platelets. D: Neutrophil rich macrothrombi composed of more than 30% neutrophils were counted in entire tissue at 10x. Values were normalized by tissue area. E and F: Images showing neutrophil macrothrombi and neutrophil aggregates that are CitH3+ in circulation in COVID-19 heart tissue. G: Image shows neutrophils with increased p65 expression (arrows) in COVID-19 tissue. Myeloperoxidase (MPO) was used to identify neutrophils and Citrullinated histone H3 (CitH3) to identify NET formation. Data represent mean ± SEM. *P < 0.05. Scale bars: 50μm (B, C, E, and F); 100μm (G).

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The American Journal of Pathology

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