New Transgenic Rat Model May Enable Better Understanding of Amyloid Buildup in Cerebral Blood Vessel (IMAGE)

Elsevier

New Transgenic Rat Model May Enable Better Understanding of Amyloid Buildup in Cerebral Blood Vessel

Caption

rTg-DI transgenic rats develop severe capillary/microvascular fibrillar amyloid accumulation accompanied by numerous microbleeds and occluded microvessels that were observed in areas of microbleeds. In (A), brain tissue from a twelve-month-old rTg-DI rat was stained for fibrillar amyloid using thioflavin-S (green) and immunolabeled for collagen type IV to identify cerebral microvessels (red); extensive microvascular amyloid is seen. Staining with hemosiderin (blue) and counterstaining with pararosanline (pink) was used to identify microhemorrhages (B) and occluded microvessels (C) in the thalamic region. Scale bars = 50 μm.

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The <em>American Journal of Pathology</em>

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