Graphical Abstract (IMAGE)

AlphaMed Press

Graphical Abstract

Caption

Autologous bone-marrow mononuclear cells were intravenously administered in patients with acute ischemic stroke as procedure outline in panel A. The non-treated patients were recruited separately. Both groups were imaged 3 time over year and neuroimaging biomarkers were developed. Integrity of the ipsilesional and contralesional cortical spinal tracts (CST) were evaluated via diffusion tensor imaging (DTI), in the rostral pons (RP), posterior limb of internal capsule (PLIC), and corona radiata (CR) as illustrated in panel B. The relative fractional anisotropy (rFA), an imaging marker of white matter integrity, was serially quantified in these three regions in each group as shown in panel C1, C2, and C3. Despite larger infarct size and severity of the treated group, the rFA either increased or stabilized as compared to the non-treated patients.

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AlphaMed Press

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