Activation of Sodium Channels (IMAGE) Johns Hopkins Medicine Caption (1) Two activated sodium channels embedded in the cell membrane are bound to each other and to a calmodulin molecule (purple). (2) Sodium channels bound to each other and to calmodulin are poised for activation but have not yet been opened by voltage change. (3) A sodium channel not bound to another channel cannot be activated by a voltage change. Credit © Anastasia Demson, 2014 Usage Restrictions Artist's permission required. License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.