TruB1 promotes the maturation of let-7 (IMAGE)

_Tokyo Medical and Dental University

TruB1 promotes the maturation of let-7

Caption

A cell-based screening for novel let-7 regulators identified a tRNA pseudouridine synthase, TruB1. TruB1 directly binds to the stem?loop structure of pri?let-7 and promotes the maturation steps of let-7, selectively.

Credit

Department of Systems BioMedicine,TMDU

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