FRUSTRATION 1 (IMAGE)

Rice University

FRUSTRATION 1

Caption

Atom-scale models by Rice University scientists based on those used to predict how proteins fold show a strong correlation between minimally frustrated binding sites and drug specificity. The funnel, a visual representation of the protein's energy landscape as it folds, helps locate those frustrated sites. Such models could lead to better-designed drugs with fewer side effects.

Credit

Illustration by Mingchen Chen/Rice University

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