Model for Lateral Transduction (IMAGE)

National University of Singapore, Yong Loo Lin School of Medicine

Model for Lateral Transduction

Caption

The induced prophage genome (blue) replicates in situ bidirectionally (1) and amplifies the adjacent bacterial DNA (gray). Phage terminase initiates in situ DNA packaging from a pac site (2), while prophage excision occurs (3) in parallel. Prophage excision produces infectious phage particles. Lateral-transducing particles are completed (4) when a headful capacity is reached. The DNA packaging machinery then proceeds to fill additional headfuls of bacterial chromosome for several hundred kilobases.

Credit

Chen J, Quiles-Puchalt N, Chiang YN, et al. Genome hypermobility by lateral transduction. <i>Science</i>. 2018. [In Press]

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