Theory of Gene Therapy by AAV-PQBP1 (IMAGE)

Tokyo Medical and Dental University

Theory of Gene Therapy by AAV-PQBP1

Caption

In Alzheimer's disease state, the nuclear scaffold protein SRRM2 and the synapse-gene regulator PQBP1 are decreased. By increasing PQBP1 in neurons, expression of synapse genes are recovered and cognitive defects are rescued in Alzheimer's patients.

Credit

Department of Neuropathology, TMDU

Usage Restrictions

None

License

Licensed content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.