CCR5 and CXCR4 (IMAGE)

Scripps Research Institute

CCR5 and CXCR4

Caption

The new Science Express study reveals the structure of the CCR5 cell surface receptor, which most strains of HIV use to enter human immune cells. This image shows CCR5 side-by-side with alternate HIV co-receptor CXCR4. While the two share similar overall architecture, their binding pockets show important differences in shape and charge distribution.

Credit

Image by Katya Kadyshevskaya, The Scripps Research Institute.

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