Kanglemycin 3D structure (IMAGE)

Penn State

Kanglemycin 3D structure

Caption

The natural antibiotic kanglemycin A binds bacterial RNA polymerase at the rifampicin binding-pocket, but maintains potency against rifampicin-resistant mutants due to two unique chemical groups (digitoxose and succinic acid) that increase its affinity to rifampicin-resistant RNA polymerase by binding just outside the rifampicin-binding pocket.

Credit

Murakami Laboratory, Penn State

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