Model of Targetable PARPi Reversible Senescence (IMAGE)

University of Montreal Hospital Research Centre (CRCHUM)

Model of Targetable PARPi Reversible Senescence

Caption

Model of targetable PARPi reversible senescence. The combination of PARPi and a senolytic was effective in preclinical models of ovarian cancer suggesting that coupling these synthetic lethalities provides a rational approach to their clinical use and may together be more effective in limiting resistance.

Credit

<em>Nature Communications</em> and Francis Rodier (CRCHUM)

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