Kinomining (IMAGE)
Caption
This shows the experimental strategy for the rational design of kinase inhibitor combination therapies. Expression profiling is used to define what kinases are expressed in cancer cells. Kinase capture using technology developed by the Johnson laboratory is used to measure which of the expressed kinases are activated in cancer cells. The kinome tree on the right shows the comprehensive capture of expressed kinases (yellow dots). Defining which kinases are activated in cancer is then used to design and test combination therapies in preclinical models of triple negative breast cancer.
Credit
Courtesy of Gary Johnson, Ph.D., University of North Carolina at Chapel Hill
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