Figure 1. Graphical Abstract of the Paper (IMAGE)

Kanazawa University

Figure 1. Graphical Abstract of the Paper

Caption

Spred1 maintains hematopoietic homeostasis by controlling both of HSC self-renewal supported by ROCK activity and tumor suppression due to inactivation of ERK signaling. Spred1 deficiency under high-fat diet condition induces the activation of ERK signaling, resulting in functional HSC failure, severe anemia, and development of leukemia. The hematopoietic abnormalities are mediated by the gut microbiota dysbiosis.

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Kanazawa University

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