Synthesis process of ZnO2@Ce6/CaP@CPPO/BSA (Z@Ce6/CaP@CB), and schematic illustration of the mechanism of Z@Ce6/CaP@CB-based synergistic therapy. (IMAGE)
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(a) Synthesis process of ZnO2@Ce6/CaP@CPPO/BSA (Z@Ce6/CaP@CB). (b) Schematic illustration of the mechanism of Z@Ce6/CaP@CB-based synergistic therapy. Z@Ce6/CaP@CB nanobombs can trigger multiple ROS storms (H2O2, 1O2, and •O2-) and Ca2+ overload-induced cell death through a cascade reaction without external energy activation and effectively activate the systemic immune response while inhibiting the growth of primary tumors.
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