Drug and Setting (IMAGE) Society for Neuroscience Caption Subjective appraisal of the emotional valence of drug experience as a function of drug and setting. The pie charts show the proportion of participants reporting the affective states detailed in the legend and illustrated in Figure 6 (see text for details) after heroin (A and B) or cocaine (C and D) use. The McNemar's test indicated significant shifts in valence as a function of the setting of drug use. Notice that a small proportion of participants reported two affective states (hatched lines) or more (grey). Credit De Pirro et al., <i>JNeurosci</i> (2018) Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.