Allosteric Machines (IMAGE)

Scripps Research Institute

Allosteric Machines

Caption

More than 50 percent of therapeutic drugs target GPCRs, including allergy and heart medication, drugs that target the central nervous system, and anti-depressants. Based on scientists' emerging understanding of GPCRs, this image represents GPCRs as complex machines, controlled not only by their pharmacological ligands, but also by sodium, cholesterol, lipids, and water.

Credit

Image by Yekaterina Kadyshevskaya, GPCR Network, The Scripps Research Institute

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