CCF Fly-Through (VIDEO)
Caption
This video depicts a fusion of data in the CCF framework The background grayscale image represents the average anatomy of 1675 individual specimens forming the basis for the common coordinate system. The colored curved lines represented sampled streamlines. The mouse cortex is a 3D sheet organized into layers where connection between the layers are typically perpendicular to the surface, suggesting a hypothetical columnar organization. The curvature of the cortex makes it difficult to visualize along this theoretical dimension. These streamlines are an estimate of these "verticals" based on the curved geometry. To see if the streamlines reflect the true curvature we compare them with real data. The hotmetal colored image are composite of multiple dataset to visualize the shape of thick-tufted dendrite of L5 pyramid neurons that were selectively labeled with Cre-dependent viral tracer injection into the Sim1-Cre_KJ18 or A930038C07Rik-Tg1-Cre driver line. Each dataset was registered to the CCF to allow the overlaying data from ~100 specimens.
Credit
Allen Institute for Brain Science
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