Lymphangiography in a Mouse Ear after Induction of Inflammation (IMAGE)
Caption
This photograph highlights the structure of both the vascular and lymphatic systems. The ear is injected intradermally with blue dye to visualize the lymphatic vessels (lymphangiography). The blood vessels are visible through the skin and appear red. The blood vessels display a branching pattern; the lymphatic capillary plexus has many looping, interconnected circular structures to promote drainage in the instance of an isolated blockage. In a normal mouse, lymphatic fluid flows in one direction: from the tip of the ear to the base of the ear or from the capillary to the lymph node. The image was taken after the induction of inflammation and shows retrograde flow, pooling, and leakage of the blue lymphatic fluid, conditions that exemplify lymphedema.
Credit
Photo credit: Kristin Johnson
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