Oligodendrocytes lacking TDP-43 produce less myelin (IMAGE)

Rockefeller University Press

Oligodendrocytes lacking TDP-43 produce less myelin

Caption

Compared with a normal cell (left), an oligodendrocyte lacking TDP-43 (center) produces less myelin (green) because it is unable to synthesize or take up sufficient amounts of cholesterol. Supplementing TDP-43–deficient cells with cholesterol (right) restores myelin production.

Credit

©2021 Ho et al. Originally published in <em>Journal of Cell Biology</em>. https://doi.org/10.1083/jcb.201910213

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