Simulated Co-evolutionary Landscape (IMAGE) Rice University Caption Scientists at Rice University and the University of Texas at Dallas constructed a simulated co-evolutionary landscape that can predict which mutants in a protein pair lead to functional signaling in bacteria. Minima in the landscape (blue) represent mutations that are predicted to function, whereas maxima (red) represent mutations that lead to nonfunctional signaling phenotypes. Credit Faruck Morcos/University of Texas at Dallas Usage Restrictions For news reporting purposes only. License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.