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The Institute of Medical Science, The University of Tokyo

Figure?

Caption

The research team generate a p16-Cre ERT2 - tdTomato mouse model to uncover the in vivo dynamics and properties of p16high cells. Single-cell RNA-seq analyses of various tissues from early middle-aged p16-CreERT2-tdTomato mice reveal that p16high cells exhibit heterogenous senescence-associated phenotypes, while elimination of p16high cells ameliorates steatosis and inflammation in a NASH model.

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�Makoto Nakanishi

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