Breast Tissue Stained for Heat Shock Factor 1 Protein (IMAGE)
Caption
This breast tissue shows both breast cancer cells (brown arrow) and normal breast epithelial cells (blue arrow). There is high expression of heat shock factor 1 protein (HSF1; stained brown) in the nuclei of tumor cells whereas normal cells have lower HSF1 expression. Nuclei without HSF1 are stained blue. In estrogen receptor (ER) positive breast cancer, the amount of HSF1 appears to be important for prognosis. High nuclear levels of HSF1 in cancer cells are associated with reduced survival while lower levels are associated with better outcome. In addition to suggesting a role in prognosis, this finding suggests that HSF1 might be a useful therapeutic target for the treatment of ER-positive breast cancer.
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Courtesy of PNAS.
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