LCAT Enzyme Structure (IMAGE)

eLife

LCAT Enzyme Structure

Caption

A small molecule (shown here in pink) with the ability to increase 'good' (HDL) cholesterol in animal models binds to the membrane-binding domain of lecithin:cholesterol acyltransferase (LCAT; shown in teal). The site is remote from the active site of the enzyme but somehow enables the transfer of lipid substrates from HDL.

Credit

Kelly Manthei and Stephanie King

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