The Disruption of the JunB Gene Prevents T-Helper Rogue Cells to Become Toxic (IMAGE)

Okinawa Institute of Science and Technology (OIST) Graduate University

The Disruption of the JunB Gene Prevents T-Helper Rogue Cells to Become Toxic

Caption

1) The normal process in which JunB can activate the Interleukin 23 (IL23) receptor gene to make the T Helper 17 cell sensitive to Interleukin 23. This potentially lead to the T Helper 17 cell to turn toxic. 2) Knocking down JunB prevents the production of Interleukin-23 receptors, and the T-Helper 17 cell cannot turn rogue any longer, but is still able to fight infections.

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OIST

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