Figure 2 (IMAGE) Kanazawa University Caption Semaphorin 3 (Sema3) produced by differentiated cancer cells in CSC niche affects CSCs. CSC niche contains various kinds of cells, including CSCs, differentiated cancer cells. endothelial cells in blood vessels, and immune cells. Sema3 is mainly produced by differentiated cancer cells in CSC niche. Credit Kanazawa University Usage Restrictions The image may only be used with appropriate caption and credit. License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.