Figure (IMAGE)

Osaka University

Figure

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We demonstrated how HCV and HCMV evade antigen presentation on MHC class I molecules. Expression of the HCV core protein or HCMV U2 protein inhibited SPP and subsequently induced degradation of MHC class I molecules. We also discovered an impairment of MHC class I molecules in CoreTg mice and patients infected with HCV. We found that the HCV core protein interfered with the interaction of SPP with HLA-A, thereby inducing accumulation of immature HLAs and subsequent HRD1-dependent degradation by proteasomes.

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Osaka University

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